Multiple Pathways to Graduation: New Routes to High School Competition

Examines three approaches -- targeted population, district-wide, and linked learning -- to raising graduation rates, benefits, and challenges; what is required for implementation; and which approaches work well for different types of districts

Fidelity of Quantum Interferometers

For a generic interferometer, the conditional probability density distribution, $p(\phi|m)$, for the phase $\phi$ given measurement outcome $m$, will generally have multiple peaks. Therefore, the phase sensitivity of an interferometer cannot be adequately characterized by the standard deviation, such as $\Delta\phi\sim 1/\sqrt{N}$ (the standard limit), or $\Delta\phi\sim 1/N$ (the Heisenberg limit). We propose an alternative measure of phase sensitivity--the fidelity of an interferometer--defined as the Shannon mutual information between the phase shift $\phi$\ and the measurement outcomes $m$. As an example application of interferometer fidelity, we consider a generic optical Mach-Zehnder interferometer, used as a sensor of a classical field. We find the surprising result that an entangled {\it N00N} state input leads to a lower fidelity than a Fock state input, for the same photon number.Comment: 4 pages, 3 figure

The Gaggle: An open-source software system for integrating bioinformatics software and data sources

BACKGROUND: Systems biologists work with many kinds of data, from many different sources, using a variety of software tools. Each of these tools typically excels at one type of analysis, such as of microarrays, of metabolic networks and of predicted protein structure. A crucial challenge is to combine the capabilities of these (and other forthcoming) data resources and tools to create a data exploration and analysis environment that does justice to the variety and complexity of systems biology data sets. A solution to this problem should recognize that data types, formats and software in this high throughput age of biology are constantly changing. RESULTS: In this paper we describe the Gaggle -a simple, open-source Java software environment that helps to solve the problem of software and database integration. Guided by the classic software engineering strategy of separation of concerns and a policy of semantic flexibility, it integrates existing popular programs and web resources into a user-friendly, easily-extended environment. We demonstrate that four simple data types (names, matrices, networks, and associative arrays) are sufficient to bring together diverse databases and software. We highlight some capabilities of the Gaggle with an exploration of Helicobacter pylori pathogenesis genes, in which we identify a putative ricin-like protein -a discovery made possible by simultaneous data exploration using a wide range of publicly available data and a variety of popular bioinformatics software tools. CONCLUSION: We have integrated diverse databases (for example, KEGG, BioCyc, String) and software (Cytoscape, DataMatrixViewer, R statistical environment, and TIGR Microarray Expression Viewer). Through this loose coupling of diverse software and databases the Gaggle enables simultaneous exploration of experimental data (mRNA and protein abundance, protein-protein and protein-DNA interactions), functional associations (operon, chromosomal proximity, phylogenetic pattern), metabolic pathways (KEGG) and Pubmed abstracts (STRING web resource), creating an exploratory environment useful to 'web browser and spreadsheet biologists', to statistically savvy computational biologists, and those in between. The Gaggle uses Java RMI and Java Web Start technologies and can be found at

Fourteen New Companions from the Keck & Lick Radial Velocity Survey Including Five Brown Dwarf Candidates

We present radial velocities for 14 stars on the California & Carnegie Planet Search target list that reveal new companions. One star, HD 167665, was fit with a definitive Keplerian orbit leading to a minimum mass for the companion of 50.3 Mjup at a separation from its host of ~5.5 AU. Incomplete or limited phase coverage for the remaining 13 stars prevents us from assigning to them unique orbital parameters. Instead, we fit their radial velocities with Keplerian orbits across a grid of fixed values for Msini and period, P, and use the resulting reduced chi-square surface to place constraints on Msini, P, and semimajor axis, a. This technique allowed us to restrict Msini below the brown dwarf -- stellar mass boundary for an additional 4 companions (HD 150554, HD 8765, HD 72780, HD 74014). If the combined 5 companions are confirmed as brown dwarfs, these results would comprise the first major catch of such objects from our survey beyond ~3 AU.Comment: 29 pages, 14 figures, accepted to Ap

The Firegoose: two-way integration of diverse data from different bioinformatics web resources with desktop applications

<p>Abstract</p> <p>Background</p> <p>Information resources on the World Wide Web play an indispensable role in modern biology. But integrating data from multiple sources is often encumbered by the need to reformat data files, convert between naming systems, or perform ongoing maintenance of local copies of public databases. Opportunities for new ways of combining and re-using data are arising as a result of the increasing use of web protocols to transmit structured data.</p> <p>Results</p> <p>The Firegoose, an extension to the Mozilla Firefox web browser, enables data transfer between web sites and desktop tools. As a component of the Gaggle integration framework, Firegoose can also exchange data with Cytoscape, the R statistical package, Multiexperiment Viewer (MeV), and several other popular desktop software tools. Firegoose adds the capability to easily use local data to query KEGG, EMBL STRING, DAVID, and other widely-used bioinformatics web sites. Query results from these web sites can be transferred to desktop tools for further analysis with a few clicks.</p> <p>Firegoose acquires data from the web by screen scraping, microformats, embedded XML, or web services. We define a microformat, which allows structured information compatible with the Gaggle to be embedded in HTML documents.</p> <p>We demonstrate the capabilities of this software by performing an analysis of the genes activated in the microbe <it>Halobacterium salinarum NRC-1 </it>in response to anaerobic environments. Starting with microarray data, we explore functions of differentially expressed genes by combining data from several public web resources and construct an integrated view of the cellular processes involved.</p> <p>Conclusion</p> <p>The Firegoose incorporates Mozilla Firefox into the Gaggle environment and enables interactive sharing of data between diverse web resources and desktop software tools without maintaining local copies. Additional web sites can be incorporated easily into the framework using the scripting platform of the Firefox browser. Performing data integration in the browser allows the excellent search and navigation capabilities of the browser to be used in combination with powerful desktop tools.</p

Effect of Sex and Menstrual Cycle on Skin Sensory Nerve Contribution to Local Heating

International Journal of Exercise Science 12(2): 1265-1279, 2019. The purpose of this study was to determine sex differences in the contribution of sensory nerves to rapid cutaneous thermal hyperemia. Healthy young females (n = 15, tested during both the early follicular (EF) and the mid-luteal (ML) phase of the menstrual cycle) and males (n = 15) had a 4 cm2 area of skin on one forearm and one leg treated with a eutectic mixture of local anesthetic (EMLA). EMLA sites, along with corresponding control sites, were instrumented with laser Doppler flowmetry probes and local skin heaters. Baseline (33 °C), rapid and sustained vasodilation (42 °C), and maximal vasodilation (44 °C) skin blood flow data were obtained and expressed as a percentage of maximal cutaneous vascular conductance (%CVCmax). Contribution of sensory nerve involvement was determined by comparing the EMLA site to its matched control site utilizing the formula [(% CVCmax control - % CVCmax treatment) / % CVCmax control] × 100. The contribution of sensory nerves to rapid cutaneous thermal hyperemia in the forearm was 24 ± 18 %CVCmax in males, 41 ± 17 %CVCmax in ML females (p = 0.02 vs. males), and 35 ± 17 %CVCmax in EF females (p \u3e 0.05 vs. males). In the leg, the contribution of sensory nerves was 16 ± 15 %CVCmax in males, 34 ± 17 %CVCmax for ML females (p = 0.02 vs. males), and 28 ± 21 %CVCmax in EF females (p \u3e 0.05 vs. males). ML females exhibited a greater contribution of sensory nerves to rapid cutaneous thermal hyperemia in the forearm and leg, possibly attributed to elevated reproductive hormones during the ML phase

Implementing just climate adaptation policy: An analysis of recognition, framing, and advocacy coalitions in Boston, U.S.A.

Cities face intersectional challenges implementing climate adaptation policy. This research contributes to scholarship dedicated to understanding how policy implementation affects socially vulnerable groups, with the overarching goal of promoting justice and equity in climate policy implementation. We apply a novel framework that integrates social justice theory and the advocacy coalition framework to incrementally assess just climate adaptation in Boston, Massachusetts in the United States. Boston made an ambitious commitment to address equity as part of its climate planning and implementation efforts. In this paper, we evaluate the first implementation stage over the period 2016–2019 during which Boston developed coastal resilience plans for three neighborhoods. Despite Boston\u27s commitment to equity, we find injustice was nevertheless reproduced through representation and coalition dynamics, the framing of problems and solutions, and a failure to recognize the priorities and lived experiences of city residents. The assessment framework presented can be adapted to evaluate how other climate adaptation initiatives advance social justice and highlights the need for incremental evaluation over short time periods to inform ongoing implementation efforts

Head Trauma not Associated with Long Term Effects on Autonomic Function

International Journal of Exercise Science 14(3): 779-790, 2021. Contact-sports can elicit concussions, which impacts autonomic function, as well as elicit repetitive head trauma, where autonomic function has not yet been assessed. The purpose of this study was to determine if differences in autonomic function exist among three groups (CTRL: healthy non-contact-sport participant, RHT: repetitive head trauma contact-sport participant, CONC: previous concussion). Forty participants (16 men and 24 women), aged 18-37 (22 ± 3), participated in the study. Participants were grouped based on their sport and concussion history (CTRL, RHT, and CONC). Body composition was measured via air displacement plethysmography. Prior to testing, participants were outfitted with equipment to evaluate heart rate, blood pressure, and cerebral-artery blood flow velocity (CBFv). The participant performed against three stimuli: deep breathing, Valsalva maneuver, and a 70° head-up tilt test. Following autonomic function testing, a YMCA submaximal cycle test was performed. All group comparisons were analyzed using a one-way ANOVA and all data are presented as means ± standard deviation. The results of this study indicated that the groups did not differ in respiratory sinus arrhythmia (CTRL: 22 ± 6 bpm, RHT: 21 ± 8 bpm, CONC: 19 ± 7 bpm, p = 0.471), Valsalva ratio (CTRL: 2.19 ± 0.39, RHT: 2.09 ± 0.37, CONC: 2.00 ± 0.47, p = 0.519), CBFv (CTRL: 47.74 ± 25.28 cm/s, RHT: 40.99 ± 10.93 cm/s, CONC: 43.97 ± 17.55 cm/s, p = 0.657), or tilt time (CTRL: 806.09 ± 368.37 sec, RHT: 943.07 ± 339.54 sec, CONC: 978.40 ± 387.98 sec, p = 0.479). However, CONC (113.24 ± 11.64 mmHg) had a significantly higher mean systolic blood pressure during the tilt test than CTRL (102.66 ± 7.79 mmHg, p = 0.026), while RHT (107.9 ± 9.0 mmHg) was not significantly different than CTRL (p = 0.39) or CONC (p = 0.319). The results of this study are the first step in determining if long-lasting deficits to the autonomic nervous system occur following a diagnosis of concussion. However, concussions do not seem to have lasting effects on autonomic function. Overwhelmingly, dysautonomia is not present during chronic recovery from concussions or in individuals with RHT from contact-sports. In the future, sex should be considered as a variable

Effects of Detritus on the Mosquito Culex pipiens: Phragmites and Schedonorus (Festuca) Invasion Affect Population Performance

Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.Species interactions that influence the performance of the exotic mosquito Culex pipiens can have important effects on the transmission risk of West Nile virus (WNV). Invasive plants that alter the vegetation communities of ephemeral ground pools may facilitate or resist the spread of C. pipiens (L.) by altering allochthonous inputs of detritus in those pools. To test this hypothesis, we combined field surveys of roadside stormwater ditches with a laboratory microcosm experiment to examine relationships between C. pipiens performance and water quality in systems containing detritus from invasive Phragmites australis (Cav.) Trin. Ex Steud., introduced Schedonorus arundinaceus (Schreb.) Dumort., or native Juncus effusus L. or Typha latifolia L. In ditches, C. pipiens abundance was unrelated to detritus species but female C. pipiens were significantly larger from ditches with S. arundinaceus and smaller with J. effusus. Larger and smaller C. pipiens were also produced in microcosms provisioned with S. arundinaceus and J. effusus, respectively, yet the per capita rate of population of change did not vary. Larger females from habitats with S. arundinaceus were likely caused by faster decay rates of S. arundinaceus and resultant increases in microbial food, but lower survival as a result of fouling and higher tannin-lignin concentrations resulted in little changes to overall population performance. Larger female mosquitoes have been shown to have greater potential for transmitting arboviruses. Our findings suggest that changed community-level interactions from plant invasions in urban ephemeral ground pools can affect the fitness of C. pipiens and possibly increase WNV risk